c-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population

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dc.creatorNalwoga, H.
dc.creatorOdida, M.
dc.creatorWabinga, H.
dc.date2013-02-20T08:25:25Z
dc.date2013-02-20T08:25:25Z
dc.date2006-08
dc.date.accessioned2018-09-04T12:33:02Z
dc.date.available2018-09-04T12:33:02Z
dc.descriptionObjective: To evaluate c-erbB-2 oncoprotein over expression in breast cancer patients of Kyadondo county and also relate this oncoprotein to histological type and grade of the tumour. Design: Cross-sectional study. Setting: Pathology Department, Faculty of Medicine, Makerere University. Subjects: Seventy two breast cancer patients who were among the 174 entered in survival study had their paraffin breast tissue blocks retrieved from archives of Pathology Department and had their c-erbB-2 determined by peroxidase-labeled streptavidin-biotin immunohistochemical method. Results: c-erbB-2 oncoprotein was over expressed in 33.3% of the tumours and correlated positively with histological grade (p = 0.007). TH oncoprotein over expression was not restricted to any particular histological type and there was no association with age of patient. Conclusion: The over expression of c-erbB-2 oncoprotein observed in one third of breast cancer patients of this African population could partly explain the observed poor survival rate reported in this community.
dc.identifierNalwoga, H., Odida, M., & Wabinga, H. (2006). c-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population. East African Medical Journal. 83(8): 63-68
dc.identifier
dc.identifierhttp://hdl.handle.net/10570/1104
dc.identifier.urihttp://hdl.handle.net/10570/1104
dc.languageen
dc.publisherEast African Medical Journal
dc.subjectUganda
dc.subjectBreast cancer
dc.titlec-erb-2 oncoprotein over-expression in breast cancer and its relationships to histology type and grade in a Uganda population
dc.typeOther
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