Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study.

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dc.creatorMugo, Nelly
dc.creatorLingappa, Jairam R.
dc.creatorKahle, Erin
dc.creatorMujugira, Andrew
dc.creatorMagaret, Amalia
dc.creatorBaeten, Jared
dc.creatorBukusi, Elizabeth A.
dc.creatorCohen, Craig R.
dc.creatorKatabira, Elly T.
dc.creatorRonald, Allan
dc.creatorKiarie, James
dc.creatorFarquhar, Guy
dc.creatorStewart, Grace John
dc.creatorMakhema, Joseph
dc.creatorEssex, M.
dc.creatorWere, Edwin
dc.creatorFife, Kenneth
dc.date2013-03-22T09:09:00Z
dc.date2013-03-22T09:09:00Z
dc.date2009-04-30
dc.date.accessioned2018-09-04T12:49:47Z
dc.date.available2018-09-04T12:49:47Z
dc.descriptionBackground: The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort. Methods: HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count $250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed. Results: Of the 3408 HIV-1 serodiscordant couples enrolled, 67% of the HIV-1 infected partners were women. Couples had cohabitated for a median of 5 years (range 2–9) with 28% reporting unprotected sex in the month prior to enrollment. Among HIV-1 susceptible participants, 86% of women and 59% of men were HSV-2 seropositive. Other laboratory diagnosed sexually transmitted infections were uncommon (,5%), except for Trichomonas vaginalis in 14% of HIV-1 infected women. Median baseline CD4 count for HIV-1 infected participants was 462cells/mcL and median HIV-1 plasma RNA was 4.2 log10 copies/mL. After adjusting for age and African region, correlates of HIV-1 RNA level included male gender (+0.24 log10 copies/mL; p,0.001) and CD4 count (20.25 and 20.55 log10 copies/mL for CD4 350–499 and .500 relative to, 350, respectively, p,0.001). Conclusions: The Partners Study successfully enrolled a cohort of 3408 heterosexual HIV-1 serodiscordant couples in Africa at high risk for HIV-1 transmission. Follow-up of this cohort will evaluate the efficacy of acyclovir for HSV-2 suppression in preventing HIV-1 transmission and provide insights into biological and behavioral factors determining heterosexual HIV-1 transmission.
dc.identifierLingappa J.R., Kahle E., Mugo N., Mujugira A., Magaret A., Baeten, J., Bukusi, E.A., Cohen, C.R., Katabira, E.T., Ronald, A., Kiarie, J., Farquhar, G., Stewart, G.J., Makhema, J., Essex, M., Were, E., Fife, K. (2009) Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study. PLoS ONE 4(4)
dc.identifier1932-6203
dc.identifier
dc.identifierhttp://hdl.handle.net/10570/1218
dc.identifier.urihttp://hdl.handle.net/10570/1218
dc.languageen
dc.publisherPublic Library of Science
dc.subjectHIV/AIDS
dc.subjectGenital herpes (HSV-2)
dc.subjectCo-infected persons
dc.subjectHIV-1 serodiscordant
dc.subjectCD4 count
dc.subjectAntiretroviral therapy
dc.subjectDiscordant couples
dc.titleCharacteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study.
dc.typeOther
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