Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?

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dc.creatorCastelnuovo, Barbara
dc.creatorNanyonjo, Agnes
dc.creatorKamya, Moses
dc.creatorOcama, Ponsiano
dc.date2012-01-25T12:01:03Z
dc.date2012-01-25T12:01:03Z
dc.date2008-06
dc.date.accessioned2018-09-04T12:32:55Z
dc.date.available2018-09-04T12:32:55Z
dc.descriptionIntroduction: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative. Case report: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda. Discussion: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse. Therefore we recommend close follow up for patients that are switched from stavudine to zidovudine and, in case lactate measurement is not possible, free programs should provide safer drugs such as abacavir and tenofovir for patients that develop hyperlactatemia.
dc.identifierCastelnuovo, B.,Nanyonjo, A.,Kamya, R.,Ocama, P. (2008). Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?, 8(2)
dc.identifier1680-6905
dc.identifierhttp://hdl.handle.net/10570/351
dc.identifier.urihttp://hdl.handle.net/10570/351
dc.languageen
dc.publisherAfrican Health Sciences
dc.subjectResource limited settings
dc.subjectAntiretroviral treatment
dc.subjectHIV/AIDS
dc.subjectUganda
dc.subjectSymptomatic hyperlactatemia
dc.subjectCD4+ count
dc.titleIs it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?
dc.typeJournal article, peer reviewed
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