Cause-Specific Mortality and the Contribution of Immune Reconstitution Inflammatory Syndrome in the First 3 Years after Antiretroviral Therapy Initiation in an Urban African Cohort

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dc.creatorCastelnuovo, Barbara
dc.creatorManabe, Yukari C
dc.creatorKiragga, Agnes
dc.creatorKamya, Moses
dc.creatorEasterbrook, Philippa
dc.creatorKambugu, Andrew
dc.date2011-12-30T18:24:26Z
dc.date2011-12-30T18:24:26Z
dc.date2009
dc.date.accessioned2018-09-04T12:32:17Z
dc.date.available2018-09-04T12:32:17Z
dc.descriptionBackground. Although many studies have reported high early mortality among patients enrolled in antiretroviral therapy (ART) programs in sub-Saharan Africa—particularly among those individuals with advanced immunodeficiency— few studies have reported the most common causes of these early deaths Methods. We determined cause-specific mortality and the contribution of immune reconstitution inflammatory syndrome (IRIS) in a well-characterized patient cohort in Kampala, Uganda, over a 36-month period of ART. Results. In a cohort of patients who initiated antiretroviral therapy in Uganda, we observed a high early mortality rate among patients with advanced disease. The most common causes of death were tuberculosis and cryptococcal meningitis. The contribution of immune reconstitution inflammatory syndrome to mortality was limited. Conclusions. We show a significant early mortality in our ART cohort in resource-limited settings that is driven by advanced human immunodeficiency virus disease and characterized by low CD4 cell counts. In our experience, the contribution of IRIS to this observed early mortality is limited.
dc.identifierCastelnuovo B, e tal Cause-Specific Mortality and the Contribution of Immune Reconstitution Inflammatory Syndrome in the First 3 Years after Antiretroviral Therapy Initiation in an Urban African Cohort ,Vol 49
dc.identifier1058-4838
dc.identifier4906-0022
dc.identifierhttp://dx.doi.org/10.1086/605500
dc.identifierhttp://hdl.handle.net/10570/279
dc.identifier.urihttp://hdl.handle.net/10570/279
dc.languageen
dc.publisherInfectious Diseases Society of America
dc.subjectReconstitution Inflammatory Syndrome
dc.subjectMortality
dc.subjectAfrican Cohort
dc.subjectAntiretroviral therapy
dc.titleCause-Specific Mortality and the Contribution of Immune Reconstitution Inflammatory Syndrome in the First 3 Years after Antiretroviral Therapy Initiation in an Urban African Cohort
dc.typeJournal article, peer reviewed
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