Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.

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dc.creatorSulggi, Less A.
dc.creatorNsobya, Samuel L.
dc.creatorYeka, Adoke
dc.creatorDokomajilar, Christian
dc.creatorRosenthal, Philip J.
dc.creatorTalisuna, Ambrose
dc.creatorDorsey, Grant
dc.date2011-12-15T16:30:12Z
dc.date2011-12-15T16:30:12Z
dc.date2006-03-13
dc.date.accessioned2018-09-04T12:53:05Z
dc.date.available2018-09-04T12:53:05Z
dc.descriptionMalaria infections in Africa frequently include multiple parasite strains.We examined the relationship between the number of infecting Plasmodium falciparum strains and the responses to 3 different combination therapies in 3072 patients with uncomplicated malaria at 7 sites in Uganda. Patients infected with _3 strains had almost 3 times the odds of treatment failure (odds ratio, 2.93 [95% confidence interval, 2.51–3.43]; P ! .001), compared with those infected with 1 or 2 strains. Our data suggest that efforts to reduce the complexity of infection in highly endemic areas through the use of intermittent presumptive therapy, improved case management, and reduction in transmission intensity may improve the efficacy of antimalarial therapies.
dc.identifierSulggi, L.A., Nsobya, S.L., Dokomajilar, C., Yeka, A., Rosenthal, P.J., Talisuna, A., Dorsey, G. (2006). Complexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. The Journal of Infectious Diseases, 193
dc.identifier0022-1899
dc.identifier1537-6613
dc.identifierhttp://hdl.handle.net/10570/255
dc.identifier.urihttp://hdl.handle.net/10570/255
dc.languageen
dc.publisherUniversity of Chicago Press
dc.subjectUganda
dc.subjectMalaria
dc.subjectPlasmodium falciparum
dc.subjectAntimalarial therapy
dc.subjectparasite strains
dc.subjectCombination therapy
dc.subjectTreatment failure
dc.subjectAntimalarial Drugs
dc.subjectAfrica
dc.titleComplexity of plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
dc.typeJournal article, peer reviewed
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