Tanrıverdi, S., et al. (2008). Inferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis

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dc.creatorTanriverdi, Sultan
dc.creatorGrinberg, Alex
dc.creatorChalmers, Rachel M
dc.creatorHunter, Paul R.
dc.creatorPetrovic, Zorana
dc.creatorAkiyoshi, Donna E.
dc.creatorLondon, Eric
dc.creatorZhang, Linghui
dc.creatorTzipori, Saul
dc.creatorTumwine, James K.
dc.creatorWidmer, Giovanni
dc.date2013-02-14T14:59:48Z
dc.date2013-02-14T14:59:48Z
dc.date2008-12
dc.date.accessioned2018-09-04T12:32:40Z
dc.date.available2018-09-04T12:32:40Z
dc.descriptionCryptosporidium parvum and Cryptosporidium hominis are two related species of apicomplexan protozoa responsible for the majority of human cases of cryptosporidiosis. In spite of their considerable public health impact, little is known about the population structures of these species. In this study, a battery of C. parvum and C. hominis isolates from seven countries was genotyped using a nine-locus DNA subtyping scheme. To assess the existence of geographical partitions, the multilocus genotype data were mined using a cluster analysis based on the nearest-neighbor principle. Within each country, the population genetic structures were explored by combining diversity statistical tests, linkage disequilibrium, and eBURST analysis. For both parasite species, a quasi-complete phylogenetic segregation was observed among the countries. Cluster analysis accurately identified recently introduced isolates. Rather than conforming to a strict paradigm of either a clonal or a panmictic population structure, data are consistent with a flexible reproductive strategy characterized by the cooccurrence of both propagation patterns. The relative contribution of each pattern appears to vary between the regions, perhaps dependent on the prevailing ecological determinants of transmission
dc.identifierInferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis. Applied Environmental Microbiology, 74(23):7227-7234
dc.identifier0099-2240
dc.identifierhttp://dx.doi.org/10.1128/AEM.01576-08
dc.identifier
dc.identifierhttp://hdl.handle.net/10570/1081
dc.identifier.urihttp://hdl.handle.net/10570/1081
dc.languageen
dc.publisherAmerican Society for Microbiology
dc.relationApplied Environmental Microbiology;74(23)
dc.subjectCryptosporidium parvum
dc.subjectCryptosporidium hominis
dc.subjectprotozoan parasites
dc.subjectintestinal cryptosporidiosis
dc.subjectoocysts apicomplexan protozoa
dc.titleTanrıverdi, S., et al. (2008). Inferences about the global population structures of Cryptosporidium parvum and Cryptosporidium hominis
dc.typeJournal article, peer reviewed
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