Pattern of neuropsychological performance among HIV positive patients in Uganda

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dc.creatorRobertson, Kevin R
dc.creatorNakasujja, Noeline
dc.creatorWong, Matthew
dc.creatorMusisi, Seggane
dc.creatorKatabira, Elly
dc.creatorParsons, Thomas D.
dc.creatorRonald, Allan
dc.creatorSacktor, Ned
dc.date2012-05-25T10:52:52Z
dc.date2012-05-25T10:52:52Z
dc.date2007
dc.date.accessioned2018-09-04T12:32:57Z
dc.date.available2018-09-04T12:32:57Z
dc.descriptionBackground: Few studies have examined cognitive functioning of HIV positive patients in sub-Saharan Africa. It cannot be assumed that HIV positive patients in Africa exhibit the same declines as patients in high-resource settings, since there are differences that may influence cognitive functioning including nutrition, history of concomitant disease, and varying HIV strains, among other possibilities. Part of the difficulty of specifying abnormalities in neuropsychological functioning among African HIV positive patients is that there are no readily available African normative databases. The purpose of the current study was to evaluate the pattern of neuropsychological performance in a sample of HIV positive patients in comparison to HIV negative control subjects in Uganda. Methods: The neuropsychological test scores of 110 HIV positive patients (WHO Stage 2, n = 21; WHO Stage 3, n = 69; WHO Stage 4, n = 20) were contrasted with those of 100 control subjects on measures of attention/concentration, mental flexibility, learning/memory, and motor functioning. Results: Analysis of covariance (ANCOVA) revealed significant group differences on measures of verbal learning and memory, speed of processing, attention and executive functioning between HIV seropositive and seronegative subjects. Conclusion: Ugandan patients with HIV demonstrated relative deficits on measures of verbal learning and memory, speed of processing, attention, and executive functioning compared to HIV negative controls. These results from a resource limited region where clades A and D are prevalentare consistent with previous findings in the developed world where clade B predominates.
dc.descriptionSupported by Bill and Melinda Gates Foundation and the Academic Alliance Foundation (which has received support from Pfizer Pharmaceuticals). MH62690, AI25868, AI50410, RR00046. Further support for this work: RO1NSMH34243, RO1MH71150.
dc.identifierRobertson, K. Nakasujja, N., Wong, M., Musisi, S., Katabira, E., Parsons, T.D., Ronald, A., Sactor, N. (2007). Pattern of neuropsychological performance among HIV positive patients in Uganda. BMC Neurology, 7(8)
dc.identifier1471-2377
dc.identifierhttp://www.biomedcentral.com/1471-2377/7/8
dc.identifierdoi:10.1186/1471-2377-7-8
dc.identifierhttp://hdl.handle.net/10570/578
dc.identifier.urihttp://hdl.handle.net/10570/578
dc.languageen
dc.publisherBioMed Central
dc.subjectNeuropsychologica
dc.subjectHIV positive
dc.subjectUganda
dc.subjectHIV/AIDS
dc.subjectSub-Saharan Africa
dc.titlePattern of neuropsychological performance among HIV positive patients in Uganda
dc.typeJournal article, peer reviewed
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