Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources

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dc.creatorColebunders, Robert
dc.creatorJohn, L.
dc.creatorHuyst, V.
dc.creatorKambugu, Andrew
dc.creatorScano, F.
dc.creatorLynen, L.
dc.date2011-12-30T19:23:43Z
dc.date2011-12-30T19:23:43Z
dc.date2006
dc.date.accessioned2018-09-04T12:32:18Z
dc.date.available2018-09-04T12:32:18Z
dc.descriptionMycobacterium tuberculosis infection accounts for probably one third of human immunodeficiency virus (HIV)related immune reconstitution inflammatory syndrome (IRIS) events, particularly in developing countries where HIV and tuberculosis (TB) co-infection is very common. Small cohort studies of HIV-positive patients with active TB treated with antiretroviral therapy (ART) suggest an incidence of TB IRIS varying between 11% and 45%.Risk factors for TB IRIS that have been suggested in certain studies but not in others include: starting ART within 6 weeks of starting TB treatment; extra-pulmonary or disseminated disease; a low CD4 lymphocyte count and a high viral load at the start of ART; and a good immunological and virological response during highly active antiretroviral therapy (HAART). It is important to agree on a clinical case definition of TB IRIS that could be used in resource-limited settings. Such a case definition could be used to determine the exact incidence and consequences of TB IRIS and would be valuable worldwide in clinical trials that are needed to answer questions on how this phenomenon could be prevented and treated.
dc.identifierColebunders, R. John, L., Huyst, V., Kambugu, A., Scano, F., Lynen, L. (2006).Tuberculosis immune reconstitution inflammatory syndrome in countries with limited resources. International Journal of Tuberculosis and Lung Disease,10(9).
dc.identifier1027-3719
dc.identifierhttp://hdl.handle.net/10570/284
dc.identifier.urihttp://hdl.handle.net/10570/284
dc.languageen
dc.publisherInternational Union Against Tuberculosis and Lung Disease
dc.subjectTuberculosis
dc.subjectTB
dc.subjectImmune reconstitution inflammatory syndrome
dc.subjectHIV/AIDS
dc.subjectHIV infection
dc.subjectMycobacterium tuberculosis
dc.subjectAntiretroviral treatment
dc.titleTuberculosis immune reconstitution inflammatory syndrome in countries with limited resources
dc.typeJournal article, peer reviewed
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