Immune reconstitution disease of the central nervous system

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dc.creatorToroka, M. Estee
dc.creatorKambugu, Andrew
dc.creatorWright, Edwina
dc.date2011-12-14T10:18:13Z
dc.date2011-12-14T10:18:13Z
dc.date2008
dc.date.accessioned2018-09-04T12:32:19Z
dc.date.available2018-09-04T12:32:19Z
dc.descriptionPurpose of review The purpose of this review is to examine the literature concerning immune reconstitution disease associated with the central nervous system infections. Recent findings Immune reconstitution disease is an adverse consequence of antiretroviral therapy, characterized by an aberrant immune response and presenting with new or worsening clinical symptoms and signs after initiation of antiretroviral therapy. Immune reconstitution disease may be associated with a broad spectrum of infectious pathogens, and has been described in the context of central nervous system infections, including progressive multifocal leucoencephalopathy, human herpesvirus infections, cryptococcal meningitis and tuberculous meningitis. Central nervous system immune reconstitution disease is a challenging condition as the clinical features are nonspecific, there is no agreed case definition, the immunopathogenesis is poorly understood, and the optimal treatment strategy is unknown. Central nervous system immune reconstitution disease appears to be associated with worse outcome than extracranial immune reconstitution disease. Summary Reports of central nervous system immune reconstitution disease are increasing and this trend is likely to continue as access to antiretroviral therapy improves in resourcelimited settings in which many central nervous system infections are endemic. Considerable challenges remain in the prevention, diagnosis and management of these conditions. Keywords HIV/AIDS, antiretroviral therapy, central nervous system, opportunistic infections, immune reconstitution disease, immune reconstitution inflammatory syndrome
dc.identifierToroka, M.,Kambugu, A.,Wright, E. (2008). Immune reconstitution disease of the central nervous system. Current Opinion in HIV and AIDS, 3
dc.identifier1746-630X
dc.identifierhttp://hdl.handle.net/10570/249
dc.identifier.urihttp://hdl.handle.net/10570/249
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.subjectHIV/AIDS
dc.subjectAntiretroviral therapy
dc.subjectCentral nervous system
dc.subjectOpportunistic infections
dc.subjectImmune reconstitution inflammatory syndrome
dc.subjectImmune reconstitution disease
dc.titleImmune reconstitution disease of the central nervous system
dc.typeJournal article, peer reviewed
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